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Predicting the Spread of Prostate Cancer with the Assistance of Stromal Cells
The Researchers at Weill Cornell Medicine have conducted a study revealing the potential significance of non-cancerous stromal cells, commonly found in and around prostate tumors. These cells, known for their role in wound healing and tissue support, may serve as indicators for assessing a tumor's likelihood to spread. Moreover, they could become targets for future prostate cancer treatments. The study, published in Nature Communications on January 8, marks the most comprehensive analysis to date of stromal cells in and around prostate tumors. By examining mouse models and human patient samples, the researchers identified eight subpopulations of stromal cells, each exhibiting distinct patterns of gene activity associated with tumors. Changes in these patterns were found to predict tumor spread, or metastasis. The research also uncovered signaling interactions among stromal cells, tumor cells, and nearby immune cells, suggesting potential targets for preventing metastasis. D...
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